Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is associated with cardiovascular outcomes after percutaneous coronary intervention in patients with type 2 diabetes - Summary - MDSpire
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Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is associated with cardiovascular outcomes after percutaneous coronary intervention in patients with type 2 diabetes
To investigate the association of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) with the risks of major adverse cardiovascular events (MACEs) following percutaneous coronary intervention (PCI) in adults with type 2 diabetes mellitus (T2DM), highlighting its potential as a novel prognostic marker.
Key Findings:
246 MACEs occurred over a follow-up period of 21.0 ± 6.6 months.
The NHHR was significantly associated with MACE incidence, with hazard ratios of 4.00 [2.47–6.48] and 6.28 [3.92–10.05] for higher NHHR quartiles.
A nonlinear relationship was observed, where a 1-unit increase in NHHR within the threshold of 3.12–5.10 raised MACE risk by 1.4-fold.
The NHHR combined with the Global Registry of Acute Coronary Events risk score had an area under the ROC curve of 0.84 for predicting post-PCI MACEs.
Interpretation:
The study suggests a nonlinear positive association between NHHR and MACE risk in T2DM patients undergoing PCI, indicating that NHHR may serve as a useful prognostic marker for early risk identification and tailored care.
Limitations:
Retrospective design may introduce selection bias, potentially affecting the reliability of the findings.
Single-center study limits generalizability of findings to broader populations.
Potential confounding factors not accounted for in the analysis may influence the results.
Conclusion:
Routine assessment of NHHR may facilitate early risk identification and tailored care for T2DM patients post-PCI, emphasizing its importance in clinical practice.
