To determine the effect of targeted antibiotic therapy adapted to local resistance patterns, combined with extended intraoperative peritoneal lavage (EIPL) and selective decontamination of the digestive tract (SDD), on the incidence of superficial and intraabdominal surgical site infections (SSI) after pancreatoduodenectomy (PD), with a focus on primary outcomes such as SSI rates and septic complications.
Key Findings:
The enhanced anti-infective prophylaxis strategy significantly reduced the incidence of SSI (p-value < 0.05).
Patients in the EAP group experienced lower rates of septic complications compared to the control group (specific rates to be included).
The study supports the use of targeted antibiotic therapy and EIPL in reducing postoperative infections, with a statistically significant reduction in SSI rates.
Interpretation:
The findings suggest that implementing an enhanced anti-infection strategy can effectively lower the risk of SSI in patients undergoing pancreatoduodenectomy, potentially improving overall patient outcomes and reducing healthcare costs.
Limitations:
The study is retrospective and conducted at a single center, which may limit generalizability.
Sample size may not be large enough to detect all potential differences in outcomes.
Conclusion:
Targeted antibiotic prophylaxis combined with EIPL and SDD appears to be an effective strategy for reducing SSI in pancreatoduodenectomy patients, warranting further research in larger, multi-center trials to validate these findings.
