Single-catheter radiofrequency pulmonary vein isolation for atrial fibrillation: a comparative evaluation - Summary - MDSpire

Single-catheter radiofrequency pulmonary vein isolation for atrial fibrillation: a comparative evaluation

  • By

  • Alessio Falasca Zamponi

  • Fariborz Tabrizi

  • Anders Englund

  • Sergej Scheel

  • Jens Olson

  • Ivar Skoger

  • Christian Basile

  • Raffaele Scorza

  • June 15, 2026

  • 0 min

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Objective:

To evaluate whether omitting the circular mapping catheter (CMC) preserves efficacy and improves efficiency in first-time pulmonary vein isolation (PVI) during radiofrequency (RF) ablation for atrial fibrillation (AF), addressing a gap in current clinical practices.

Approach:
    Key Findings:
    • CMC-free cases had shorter procedures (105 vs. 120 min, p < 0.001), indicating improved efficiency.
    • Lower fluoroscopy time in CMC-free cases (4 vs. 6 min, p < 0.001), which may reduce patient exposure to radiation.
    • Reduced radiation dose in CMC-free cases (150 vs. 220 cGy·cm2, p < 0.001), enhancing safety.
    • RF time and energy were lower in CMC-free cases (2083 vs. 2343 s, p = 0.026; 71582 vs. 77335 J, p = 0.035), suggesting a more efficient procedure.
    • 12-month efficacy was comparable between groups (adjusted HR: 1.03, 95% CI: 0.58–1.84; p = 0.92), supporting the non-inferiority of the CMC-free approach.
    • Recurrences did not differ significantly (adjusted IRR: 0.61, 95% CI: 0.30–1.21; p = 0.16), indicating similar long-term outcomes.
    Interpretation:

    In CLOSE-style first-time RF PVI, a CMC-free workflow improved procedural efficiency without significant differences in 12-month arrhythmia outcomes, suggesting potential for broader application in clinical practice.

    Limitations:
    • The study was non-randomized, which may introduce selection bias; future studies should consider randomized designs to validate findings.
    • Findings are hypothesis-generating and require confirmation through prospective randomized studies to establish safety and efficacy.
    Conclusion:

    The CMC-free approach may enhance efficiency in RF PVI for AF without compromising efficacy, warranting further investigation to confirm its impact on patient care.

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