Value of point-of-care ultrasound in the early identification of left ventricular dysfunction and prognostic assessment in cancer patients complicated by sepsis - Summary - MDSpire
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Value of point-of-care ultrasound in the early identification of left ventricular dysfunction and prognostic assessment in cancer patients complicated by sepsis
To assess left ventricular (LV) function using point-of-care ultrasound (POCUS) and determine its prognostic value in cancer patients complicated by sepsis, highlighting the significance of early detection.
Key Findings:
Patients with LV dysfunction (LVEF < 50%) had a significantly higher 28-day mortality rate (p < 0.05).
e' velocity was identified as an independent predictor of 28-day survival (HR = 0.609, 95% CI: 0.454–0.818; p = 0.001).
The combination of e' and cardiac troponin I (cTnI) showed strong predictive value (AUC = 0.823).
The composite prognostic model (e', cTnI, SOFA, APACHE II) achieved the highest predictive accuracy (AUC = 0.874), with statistical significance noted.
Interpretation:
Lower POCUS-derived e′ is associated with worse 28-day survival in cancer patients with sepsis, indicating its potential role in identifying high-risk patients and guiding clinical decisions.
Limitations:
The study does not establish a robust prognostic model to guide treatment decisions, and potential biases inherent in retrospective studies should be considered.
Findings are preliminary and require validation in larger prospective cohorts.
Conclusion:
Early measurement of e′ may help identify high-risk cancer patients complicated by sepsis, but further research is needed to validate these findings and their clinical applicability.
