Partial Oral Therapy for Infective Endocarditis Among Adult Infectious Diseases Physicians in the United States: An Emerging Infections Network Survey - Summary - MDSpire
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Partial Oral Therapy for Infective Endocarditis Among Adult Infectious Diseases Physicians in the United States: An Emerging Infections Network Survey
To quantify current use of partial oral therapy (POT) for infective endocarditis (IE), identify organism-specific practices, and delineate barriers and facilitators among U.S. adult infectious diseases physicians, ensuring clarity on what POT entails.
Key Findings:
Only 16% of respondents never used POT.
53% used it in ≤10% of cases.
POT usage increased with higher caseloads and fewer years in clinical practice.
66% were comfortable using POT for Streptococcus spp., but only 19% for methicillin-resistant Staphylococcus aureus.
Key decision drivers included availability of an active oral agent (75%) and the pathogen involved (69%).
Major barriers included fear of relapse (72%) and adherence concerns (53%).
Interpretation:
U.S. adult ID physicians adopt POT for IE sparingly, influenced by clinical experience and specific pathogens, with significant barriers to broader implementation that need to be addressed.
Limitations:
The survey had a 34% response rate, which may limit generalizability due to potential non-response bias.
Self-reported data may introduce bias.
Conclusion:
Wider adoption of POT for IE may require updated treatment guidelines, more clinical trial data, and improved access to outpatient antimicrobial therapy services, alongside addressing identified barriers.
