The effect of intensive treatment of hypertension on cardiovascular events, generalized to middle-aged to older Americans living with hypertension - Summary - MDSpire
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The effect of intensive treatment of hypertension on cardiovascular events, generalized to middle-aged to older Americans living with hypertension
To generalize the SPRINT trial results to US adults eligible for intensive hypertension treatment and estimate the effect on cardiovascular events.
Key Findings:
HR for cardiovascular disease events was 0.76 (95% CI: 0.53, 1.08) for intensive vs standard treatment.
5-year risk difference for cardiovascular events was -2.2% (95% CI: -5.3%, 1.6%).
HR for serious adverse events was 0.97 (95% CI: 0.83, 1.13).
Interpretation:
Intensive hypertension management may provide similar benefits in reducing cardiovascular events and adverse events in the broader target population compared to the original SPRINT trial.
Limitations:
Differences in demographics and health status between SPRINT participants and the general target population.
Potential biases in applying trial results to a broader population.
Conclusion:
The findings suggest that intensive treatment of hypertension can be beneficial for middle-aged and older adults in the US, aligning with SPRINT trial outcomes.
