To systematically evaluate the bidirectional association between obstructive lung diseases (OLD) and inflammatory bowel disease (IBD).
Approach:
Study Design: Systematic search of PubMed, Embase, and Cochrane Library databases for observational studies published up to 30 June 2023.
Key Findings:
IBD is associated with an increased risk of subsequent COPD.
COPD is generally associated with increased risks of subsequent Crohn's disease (CD) and ulcerative colitis (UC), though with substantial heterogeneity.
Evidence suggests a positive association between bronchiectasis and IBD, but the pooled estimate for IBD and subsequent bronchiectasis is imprecise.
Asthma shows a consistent association with IBD, with IBD linked to increased risk of subsequent asthma and vice versa.
The bidirectional association is stronger and more consistent for CD than for UC.
Interpretation:
The systematic review and meta-analysis supports positive associations between OLD and IBD, particularly for COPD with IBD subtypes and for asthma with IBD, especially CD.
Limitations:
The pooled estimate for IBD and subsequent bronchiectasis was imprecise.
Substantial heterogeneity was observed in COPD-to-CD and COPD-to-UC analyses.
Conclusion:
These associations should be interpreted according to the OLD subtype and age context, with clinicians advised to assess respiratory comorbidities in IBD patients.
A structured overview of recent FDA recalls, corrections, and alerts involving medications, ventilators, insulin delivery systems, cardiovascular devices, anesthesia products, and other equipment used in clinical practice.
