To evaluate functional capacity in patients with Pseudoxanthoma elasticum (PXE) compared with healthy references using the 6-minute walking test (6MWT).
Approach:
Key Findings:
The mean observed WD in women with PXE was 533 ± 96 meters, significantly lower than reference values by 32 meters.
Men with PXE walked significantly shorter distances than expected, with a mean WD of 496 ± 109 meters in those with PAD, below reference values by 60 meters.
111 patients (69%) had a lower WD compared to healthy references, with significant reductions observed in younger patients.
Interpretation:
Limitations:
PAD status was only available for 92 of 162 patients, although this subset was representative of the total cohort.
Federal prosecutors allege that a Florida physician and research staff fabricated clinical trial records that were submitted into database systems used to evaluate investigational drugs.
