To evaluate functional capacity in patients with Pseudoxanthoma elasticum (PXE) compared with healthy references using the 6-minute walking test (6MWT).
Approach:
Key Findings:
The mean observed WD in women with PXE was 533 ± 96 meters, significantly lower than reference values by 32 meters.
Men with PXE walked significantly shorter distances than expected, with a mean WD of 496 ± 109 meters in those with PAD, below reference values by 60 meters.
111 patients (69%) had a lower WD compared to healthy references, with significant reductions observed in younger patients.
Interpretation:
Limitations:
PAD status was only available for 92 of 162 patients, although this subset was representative of the total cohort.
Research highlights expanding diagnostic capabilities but persistent gaps in antiviral therapy and vaccine coverage for pediatric enterovirus infections.
