The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis - Summary - MDSpire

The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis

  • By

  • Wendi Zhang

  • Geng Chang

  • Zhen Mu

  • June 5, 2026

  • 0 min

Share

Objective:

To clarify the association between the systemic immune-inflammation index (SII) and post-stroke depression (PSD) in adult stroke patients.

Key Findings:
  • Seven studies involving 2,780 patients were included, with 822 developing PSD.
  • High SII at admission was significantly associated with an increased risk of PSD (OR = 2.14, 95% CI: 1.74–2.64).
  • Sensitivity analyses confirmed stability of findings across various subgroups.
Interpretation:

Elevated SII may be independently associated with an approximately twofold increased risk of PSD.

Limitations:
  • Inconsistencies in previous studies regarding SII and PSD.
  • Limited by small sample sizes and heterogeneous methodologies in included studies.
Conclusion:

SII may serve as a simple and accessible inflammatory biomarker for early identification of patients at higher risk of developing PSD.

Original Source(s)

The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis

  • by Wendi Zhang, Geng Chang, Zhen Mu

  • June 5, 2026

Related Content

Association of upper limb motor function with muscle tone changes and quality of life in the subacute phase after stroke: a prospective cohort study

Association between neurodegenerative plasma biomarkers and geriatric depression in older adults with and without clinical dementia in Kinshasa, Democratic Republic of the Congo

Complex Stroke Case Highlights Importance of Rapid Recognition and Advanced Neurovascular Care

For 68-year-old Ana Barrios de Salamanca, the sudden onset of a stroke brought an incredible display of quick thinking from a very young family member, her 6-year-old granddaughter. It also brought a complex medical challenge that required precision from specialized medical and surgical care teams at Baptist Health Miami Neuroscience Institute and Baptist Health Brain & Spine Care.

  • by

  • May 28, 2026

  • 9 min