Preoperative prediction of microvascular invasion in hepatocellular carcinoma ≤5 cm based on contrast-enhanced ultrasound features and LI-RADS categorization: a multicenter study - Summary - MDSpire
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Preoperative prediction of microvascular invasion in hepatocellular carcinoma ≤5 cm based on contrast-enhanced ultrasound features and LI-RADS categorization: a multicenter study
To investigate the predictive value of contrast-enhanced ultrasound (CEUS) features combined with Liver Imaging Reporting and Data System (LI-RADS) categorization for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) ≤5 cm.
Approach:
Study Design: Multicenter retrospective study enrolling adult patients with HCC ≤5 cm who underwent CEUS from January 2018 to December 2025.
Data Analysis: Utilized LASSO regression and multivariate logistic analysis to screen risk factors and establish MVI prediction models.
Model Development: Developed three models: a clinical model, an ultrasound model, and a combined model, evaluated using AUC, calibration curves, DCA, and the Hosmer-Lemeshow test.
Key Findings:
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Interpretation:
Limitations:
Retrospective design may introduce selection bias.
Results may not be generalizable beyond the studied population.
