Objective:

To explore the application effect of the Internet Plus Nursing mode (INM) on managing patients taking oral warfarin in a randomized controlled trial with a 6-month follow-up period.

Approach:

• Study Design: A prospective, single-center, randomized controlled trial with a 6-month follow-up period.
• Participants: 122 patients on long-term oral warfarin were randomly divided into an INM group (n = 61) and a usual care group (n = 61).
• Intervention: The INM group received INM-based health education intervention, while the usual care group received a routine education manual.
• Follow-Up: Patients were followed up for 6 months, with INR-related outcomes reported at 10 days and 1 month.

Key Findings:

• The INM group had significantly higher INR compliance rates at 10 days (98.33% vs. 86.54%, P = 0.045) and 1 month (86.67% vs. 57.69%, P = 0.015).
• INM group showed higher INR monitoring rates at 10 days (98.33% vs. 84.62%, P = 0.017) and 1 month (96.67% vs. 80.77%, P = 0.036).
• Medication adherence was significantly better in the INM group (88.33% vs. 48.08%, P < 0.001).
• Health knowledge scores were higher in the INM group (29.1 ± 2.1 vs. 22.8 ± 3.0, P < 0.001).
• Patient satisfaction was higher in the INM group (98.33% vs. 90.38%, P = 0.020).
• No significant differences in complication or readmission rates between groups (96.67% vs. 94.23%, P > 0.05).

Interpretation:

The INM significantly enhances patients' understanding of warfarin therapy, improves medication adherence, and boosts self-management skills over a 6-month follow-up.

Limitations:

• The study was conducted at a single center, which may limit the generalizability of the findings to broader patient populations.

Conclusion:

The INM model improves warfarin management through enhanced education and monitoring.