Tricuspid Regurgitation and Impact of Surgical Valve Intervention in the Single Ventricle Reconstruction Trial - Summary - MDSpire

Tricuspid Regurgitation and Impact of Surgical Valve Intervention in the Single Ventricle Reconstruction Trial

  • By

  • J. F. Cnota

  • S. M. Chowdhury

  • A. Floh

  • R. Gongwer

  • B. H. Goot

  • J. P. Jacobs

  • M. A. Jolley

  • S. Kirmani

  • D. J. LaPar

  • J. C. Levine

  • A. B. Lewis

  • R. H. Pignatelli

  • C. Pizarro

  • T. C. Slesnick

  • T. Thorsson

  • F. Trachtenberg

  • D. T. Truong

  • J. W. Newburger

  • P. C. Frommelt

  • February 18, 2026

  • 0 min

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Objective:

To analyze the impact of tricuspid regurgitation (TR) severity on clinical outcomes, including survival and need for transplantation, in patients with single right ventricle anomalies undergoing staged surgical interventions.

Key Findings:
  • Significant increase in > mild TR from baseline to post-Norwood (12.1% to 24.3%, p < 0.001), indicating a concerning trend in TR severity post-surgery.
  • Stable prevalence of > mild TR from post-Norwood to age 6 years.
  • 54% of participants had ≤ mild TR at all echocardiograms; only 4% had > mild TR consistently.
Interpretation:

Increased TR severity post-surgery is common, but many patients maintain ≤ mild TR over time, suggesting potential for favorable outcomes despite initial TR severity, highlighting the need for careful monitoring.

Limitations:
  • Analysis did not include detailed assessment of TR severity over time post-surgery, which may overlook important trends.
  • Exclusion of patients who underwent biventricular conversion may limit generalizability of findings to the broader population.
Conclusion:

Surgical interventions in single ventricle patients show variable TR outcomes, with many achieving stable TR levels, indicating the need for ongoing monitoring and potential interventions to optimize patient outcomes.

Original Source(s)

Tricuspid Regurgitation and Impact of Surgical Valve Intervention in the Single Ventricle Reconstruction Trial

  • by J. F. Cnota, S. M. Chowdhury, A. Floh, R. Gongwer, B. H. Goot, J. P. Jacobs, M. A. Jolley, S. Kirmani, D. J. LaPar, J. C. Levine, A. B. Lewis, R. H. Pignatelli, C. Pizarro, T. C. Slesnick, T. Thorsson, F. Trachtenberg, D. T. Truong, J. W. Newburger, P. C. Frommelt

  • February 18, 2026

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