Objective:

To assess UroVysion diagnostic performance and its association with adverse pathological features in patients with upper tract lesions and negative urinary cytology.

Approach:

• Design and population: Retrospective cohort at two hospitals, covering January 2012 to June 2025. The analysis included 1,256 patients with imaging-detected upper tract lesions, negative cytology, and preoperative UroVysion testing.
• Reference diagnosis: UTUC was confirmed in 1,007 patients; 249 were classified as non-cancer based on benign surgical pathology or negative biopsy with no imaging progression for at least six months.
• Analysis: Diagnostic performance was assessed using sensitivity, specificity, predictive values, and accuracy. Logistic regression evaluated associations between UroVysion positivity and adverse pathological features.

Key Findings:

• The provided article context reports the cohort composition but does not include diagnostic-performance estimates or results of the pathological association analyses.

Interpretation:

The supplied context describes the study rationale and methods but provides insufficient results to characterize UroVysion accuracy or its relationship with pathological features.

Limitations:

• The study was retrospective and conducted at two hospitals.
• Historical cytology results were not retrospectively reclassified under The Paris System.
• The provided context ends before the study’s diagnostic and pathological results.

Sources:

• Article context supplied in the prompt