To assess baseline α-syn CSF SAA kinetic parameters, their longitudinal variations, and associations with clinical outcomes in a longitudinal cohort of Lewy Body Disorder patients.
Key Findings:
196 individuals showed α-syn seeding activity; 170 remained positive, while 26 converted from negative to positive.
LBD-converters had lower Nrep and longer Lag at baseline compared to persistent positives.
Nrep increased and Lag decreased longitudinally, particularly in asymptomatic LBD and Parkinson's disease without dementia.
Baseline Nrep predicted subsequent dementia appearance in the cohort and Parkinson's subgroup.
Interpretation:
The α-syn SAA parameters Nrep and Lag correlate with LBD stage and dementia development, indicating their potential as biomarkers for monitoring disease progression and guiding treatment decisions.
Limitations:
The study is limited to a specific cohort and may not generalize to all Lewy Body Disorder patients.
Longitudinal data collection was dependent on participant retention and compliance, which may introduce bias.
Conclusion:
The findings support the use of α-syn SAA kinetic parameters to monitor disease progression and therapeutic response in Lewy Body Disorder, highlighting their potential role in future research.
by Andrea Mastrangelo, Angela Mammana, Sara Hall, Erik Stomrud, Corrado Zenesini, Marcello Rossi, Shorena Janelidze, Alice Ticca, Sebastian Palmqvist, Franco Magliocchetti, Simone Baiardi, Niklas Mattsson-Carlgren, Oskar Hansson, Piero Parchi
