Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions - Summary - MDSpire
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Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions
To assess the relationships among genetic polymorphisms, adipokine levels, and clinical and metabolic indicators in patients with varying degrees of obesity, and to analyze changes in anthropometric and metabolic parameters after specific bariatric interventions.
Key Findings:
Resistin and leptin levels increase, while adiponectin and ghrelin levels decrease with increasing obesity (p < 0.05).
The rs1137101 and rs696217 polymorphisms are associated with the degree of obesity, with the A allele of rs1137101 being less common in patients with stage III obesity.
Bariatric interventions significantly reduce BMI and body weight, improve glycemic control, and normalize hormonal profiles (p < 0.001).
The T allele of rs696217 and G allele of rs1137101 influence weight dynamics and hormonal changes post-surgery, suggesting a genetic basis for treatment response.
Interpretation:
The hormonal profile and genetic variants rs1137101 and rs696217 impact obesity severity and bariatric treatment effectiveness, suggesting potential for personalized therapy based on genetic testing, which could enhance treatment outcomes.
Limitations:
Limited sample size of 76 patients may affect generalizability.
Observational design may limit causal inferences.
Potential biases inherent in observational studies could influence results.
Conclusion:
Genetic testing may aid in predicting outcomes and personalizing therapy for obesity treatment, particularly following bariatric surgery.
