Objective:

To evaluate the effectiveness of various peptide-based therapies, including both oral and topical formulations, in improving signs of skin aging.

Approach:

Key Findings:

• Peptide therapies showed modest improvements in skin hydration, brightness, and wrinkle appearance compared to placebo.
• Oral formulations demonstrated stronger evidence of effectiveness than topical therapies.
• Hydration benefits were consistent, while improvements in skin elasticity and density were not statistically significant. Results for skin roughness were borderline and should be interpreted cautiously.

Interpretation:

Peptides may enhance certain cosmetic skin parameters, but effects vary across different aging markers, highlighting the need for cautious interpretation.

Limitations:

• Substantial heterogeneity in peptide types, dosing, and outcome measurement methods.
• Limited number of studies on topical formulations restricts comparative analysis.
• Lack of standardized assessment techniques across trials, particularly for topical therapies.

Conclusion:

Peptide-based therapies may serve as a noninvasive adjunct in aesthetic dermatology, particularly oral formulations, but further standardized research is needed, especially to compare oral and topical formulations.

Sources:

• Frontiers in Medicine
Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.