To evaluate the effectiveness of various peptide-based therapies, including both oral and topical formulations, in improving signs of skin aging.
Key Findings:
Peptide therapies showed modest improvements in skin hydration, brightness, and wrinkle appearance compared to placebo.
Oral formulations demonstrated stronger evidence of effectiveness than topical therapies.
Hydration benefits were consistent, while improvements in skin elasticity and density were not statistically significant. Results for skin roughness were borderline and should be interpreted cautiously.
Interpretation:
Peptides may enhance certain cosmetic skin parameters, but effects vary across different aging markers, highlighting the need for cautious interpretation.
Limitations:
Substantial heterogeneity in peptide types, dosing, and outcome measurement methods.
Limited number of studies on topical formulations restricts comparative analysis.
Lack of standardized assessment techniques across trials, particularly for topical therapies.
Conclusion:
Peptide-based therapies may serve as a noninvasive adjunct in aesthetic dermatology, particularly oral formulations, but further standardized research is needed, especially to compare oral and topical formulations.
