Association of SARS-CoV-2 With Health-related Quality of Life 1 Year After Illness Using Latent Transition Analysis - Summary - MDSpire

Association of SARS-CoV-2 With Health-related Quality of Life 1 Year After Illness Using Latent Transition Analysis

  • By

  • Lauren E Wisk

  • Michael Gottlieb

  • Peizheng Chen

  • Huihui Yu

  • Kelli N O’Laughlin

  • Kari A Stephens

  • Graham Nichol

  • Juan Carlos C Montoy

  • Robert M Rodriguez

  • Michelle Santangelo

  • Kristyn Gatling

  • Erica S Spatz

  • Arjun K Venkatesh

  • Kristin L Rising

  • Mandy J Hill

  • Ryan Huebinger

  • Ahamed H Idris

  • Michael Willis

  • Efrat Kean

  • Samuel A McDonald

  • Joann G Elmore

  • Robert A Weinstein

  • for the INSPIRE Group

  • June 10, 2025

  • 0 min

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Objective:

To compare health-related quality of life (HRQoL) changes in adults with COVID-19–like illness who tested positive for SARS-CoV-2 versus those who tested negative.

Key Findings:
  • COVID+ participants were more likely to return to optimal HRQoL compared to COVID− participants.
  • Significant recovery in physical HRQoL was observed by 3 months post-infection.
  • Mental HRQoL improvements were noted by 9 months post-infection.
  • Approximately 20% of participants reported suboptimal HRQoL at 3 to 12 months after infection.
Interpretation:

COVID-19 infection has a differential impact on physical and mental HRQoL, with physical recovery occurring more rapidly than mental recovery.

Limitations:
  • The study may have selection bias due to voluntary participation.
  • The reliance on self-reported measures may affect the accuracy of HRQoL assessments.
  • The study's findings may not be generalizable to populations outside the study cohort.
Conclusion:

While physical HRQoL improves significantly within 3 months post-COVID-19 infection, mental HRQoL recovery takes longer, highlighting the need for ongoing support for affected individuals.

Original Source(s)

Association of SARS-CoV-2 With Health-related Quality of Life 1 Year After Illness Using Latent Transition Analysis

  • by Lauren E Wisk, Michael Gottlieb, Peizheng Chen, Huihui Yu, Kelli N O’Laughlin, Kari A Stephens, Graham Nichol, Juan Carlos C Montoy, Robert M Rodriguez, Michelle Santangelo, Kristyn Gatling, Erica S Spatz, Arjun K Venkatesh, Kristin L Rising, Mandy J Hill, Ryan Huebinger, Ahamed H Idris, Michael Willis, Efrat Kean, Samuel A McDonald, Joann G Elmore, Robert A Weinstein, for the INSPIRE Group

  • June 10, 2025

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