Clinical Characteristics of 6578 Adult Patients With Cholera Admitted to Community and Referral Cholera Treatment Centers in Lusaka, Zambia, October 2023 to April 2024 - Summary - MDSpire

Clinical Characteristics of 6578 Adult Patients With Cholera Admitted to Community and Referral Cholera Treatment Centers in Lusaka, Zambia, October 2023 to April 2024

  • By

  • Nyuma Mbewe

  • Tadatsugu Imamura

  • Suilanji Sivile

  • Annel Sinkala

  • Paul Zulu

  • Chitalu Chanda

  • Neil Naik

  • Nawa Kalima

  • Roy Tepa

  • Kabaso Mwewa

  • Kenneth Kapololwe

  • Anchindika Mugala

  • Aggrey Mweemba

  • Davie Simwaba

  • Muzala Kapina

  • Kelvin Mwangilwa

  • Lalisa Nambeya

  • Sophia Msiska

  • Aspha Choonga

  • Bob Chirwa

  • Shingo Mitsushima

  • Yuuki Tsuchihashi

  • Nathan Kapata

  • Taro Kamigaki

  • Lloyd Mulenga

  • Roma Chilengi

  • May 8, 2025

  • 0 min

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Objective:

To identify the clinical characteristics of adult cholera patients hospitalized in Lusaka during the significant outbreak from October 2023 to April 2024 and determine factors associated with severe clinical outcomes.

Key Findings:
  • Total of 6,578 adult cholera cases identified with an overall case fatality rate of 1.0%.
  • Highest case fatality rate of 4.1% observed in a referral CTC for patients with underlying conditions.
  • Age (odds ratio 1.05), HIV infections (odds ratio 5.68), diabetes mellitus (odds ratio 8.21), and severe dehydration at admission (odds ratio 5.97) were independently correlated with fatal outcomes.
Interpretation:

Clinical factors such as age, underlying conditions, and disease severity at admission significantly influence the outcomes of adult cholera patients, highlighting the need for targeted management strategies to improve patient care.

Limitations:
  • The retrospective nature may limit the completeness of clinical data, potentially affecting the reliability of the findings.
  • Findings may not be generalizable to other regions or populations due to specific local factors.
Conclusion:

Enhanced case management strategies for high-risk groups, based on identified clinical factors, could significantly reduce the case fatality rate during cholera outbreaks.

Original Source(s)

Clinical Characteristics of 6578 Adult Patients With Cholera Admitted to Community and Referral Cholera Treatment Centers in Lusaka, Zambia, October 2023 to April 2024

  • by Nyuma Mbewe, Tadatsugu Imamura, Suilanji Sivile, Annel Sinkala, Paul Zulu, Chitalu Chanda, Neil Naik, Nawa Kalima, Roy Tepa, Kabaso Mwewa, Kenneth Kapololwe, Anchindika Mugala, Aggrey Mweemba, Davie Simwaba, Muzala Kapina, Kelvin Mwangilwa, Lalisa Nambeya, Sophia Msiska, Aspha Choonga, Bob Chirwa, Shingo Mitsushima, Yuuki Tsuchihashi, Nathan Kapata, Taro Kamigaki, Lloyd Mulenga, Roma Chilengi

  • May 8, 2025

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