Case Report: Benign colonic schwannoma with restricted diffusion mimicking malignancy - Summary - MDSpire

Case Report: Benign colonic schwannoma with restricted diffusion mimicking malignancy

  • By

  • Hao Zhu

  • Xiuya Cen

  • Chunchun Li

  • Deen Shi

  • Yongchou Li

  • Shitian Bao

  • Wei Weng

  • July 9, 2026

  • 0 min

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Objective:

To report a case of benign colonic schwannoma that exhibited imaging features typically associated with malignancy, highlighting the diagnostic challenges.

Approach:
  • Case Presentation: A 43-year-old woman with abdominal pain and altered bowel habits underwent colonoscopy revealing a large submucosal mass. Imaging suggested malignancy, but histopathology confirmed a benign schwannoma.
Key Findings:
  • The colonic schwannoma displayed pronounced restricted diffusion on MRI and prominent mesocolic lymphadenopathy, which suggested malignancy.
  • Histopathology confirmed the diagnosis of benign gastrointestinal schwannoma despite preoperative imaging suggesting malignancy.
  • All harvested mesocolic lymph nodes showed reactive hyperplasia without metastasis.
Interpretation:

Benign colonic schwannomas can mimic malignancy due to imaging features such as restricted diffusion and lymphadenopathy.

Limitations:
  • The case is based on a single patient, limiting generalizability.
  • Imaging features may vary in different cases of schwannoma.
Conclusion:

Imaging and biopsy may not exclude malignancy in cases of benign colonic schwannoma, and definitive diagnosis relies on histopathology and immunohistochemistry.

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