Real-World Study on the Effectiveness and Breast Safety Analysis of Hormone Replacement Therapy During Menopause - Summary - MDSpire

Real-World Study on the Effectiveness and Breast Safety Analysis of Hormone Replacement Therapy During Menopause

  • By

  • Wang, Yingxia

  • Liu, Yaqin

  • Zeng, Jing

  • Wang, Mengyi

  • Li, Yuhuan

  • Wu, Yinglan

  • Gao, Jie

  • Chen, Xia

  • May 21, 2026

  • 0 min

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Objective:

To evaluate the effects of 24-month menopausal hormone therapy (MHT) on bone mineral density (BMD), menopausal symptoms, and breast safety in postmenopausal women.

Key Findings:
  • Prevalence of osteoporosis decreased from 18.0% to 14.0% and low bone mass from 27.4% to 21.4% (P < 0.001).
  • Significant differences in BMD were observed at all post-treatment time points (all P < 0.001).
  • Mean Kuppermann score improved from 40.17 ± 6.04 at baseline to 11.38 ± 4.90 at 24 months (P < 0.001).
  • No significant changes in breast density, volume, or prevalence of calcifications or masses (all P > 0.05).
Interpretation:

Limitations:
Conclusion:

Original Source(s)

Real-World Study on the Effectiveness and Breast Safety Analysis of Hormone Replacement Therapy During Menopause

  • by Wang, Yingxia , Liu, Yaqin , Zeng, Jing , Wang, Mengyi , Li, Yuhuan , Wu, Yinglan , Gao, Jie , Chen, Xia

  • May 21, 2026

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