Personalized management of glucokinase-related monogenic diabetes (GCK-MODY) during pregnancy: a case report
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By
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Ana Filipa Bolas
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João Oliveira Torres
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Paula Bogalho
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José Silva-Nunes
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May 28, 2026
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Objective:
To present a case study that highlights the management challenges of GCK-MODY during pregnancy.
Key Findings:
- The patient had a variant of uncertain significance in the GCK gene, which was classified as such due to its unclear implications for management.
- Glycemic control was achieved through a tailored insulin regimen and continuous glucose monitoring (CGM).
- The patient delivered a healthy male newborn at 36 weeks and 2 days.
Interpretation:
This case illustrates the management of GCK-MODY in pregnancy, particularly with uncertain genetic findings and the absence of fetal genotyping.
Limitations:
- The genetic variant was classified as of uncertain significance, which complicated management.
- Fetal genotype was not determined due to the couple's choice against invasive testing.
Conclusion:
The case highlights the importance of a multidisciplinary and individualized approach in managing GCK-MODY during pregnancy.
