To establish an outcome-derived threshold for central blood pressure (cBP) and evaluate its clinical utility in stratifying cardiovascular (CVD) risk.
Key Findings:
49.84% of participants had brachial and central normotension.
Isolated brachial hypertension was found in 2.23% of participants, while isolated central hypertension was 3.65%.
Concordant brachial and central hypertension accounted for 44.28%.
Individuals with isolated central hypertension had a hazard ratio of 1.70 for cardiovascular events compared to those with concordant normotension.
Interpretation:
Incorporating central BP improved the prediction of CVD risk beyond traditional brachial BP measurement alone, highlighting the importance of assessing central BP.
Limitations:
The study is retrospective and relies on existing data, which may have inherent biases.
Central BP measurement is not routinely endorsed in clinical practice, limiting generalizability.
Conclusion:
A diagnostic threshold of 135 mmHg for central SBP can help better assess cardiovascular disease risk in adults, with implications for clinical practice.
