Health economic simulation modeling of an AI-enabled clinical decision support system for coronary revascularization - Summary - MDSpire

Health economic simulation modeling of an AI-enabled clinical decision support system for coronary revascularization

  • By

  • Tom Mullie

  • Arjun Puri

  • Emma Bogner

  • Bryan Har

  • Colm J. Murphy

  • Robert C. Welsh

  • Benjamin Tyrrell

  • Christopher L. F. Sun

  • Joon Lee

  • February 16, 2026

  • 0 min

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Objective:

To evaluate the economic value of an AI-enabled coronary revascularization decision support system using real-world data, focusing on cost-effectiveness and patient outcomes.

Key Findings:
  • 72.4% of treatment decisions shifted to economically optimized options at a willingness-to-pay of $50,000 per QALY, indicating significant potential for cost savings.
  • Average cost saving of $22,960 and QALY gain of $22,439 per patient, demonstrating the economic benefits of AI integration.
  • In a conservative scenario, 53.2% of decisions shifted, with a QALY gain of $32,214 per patient, highlighting the robustness of AI recommendations even under limited adoption.
Interpretation:

AI can enhance the economic value of treatment decisions by reducing costs and improving patient outcomes through optimized decision-making, leading to better resource allocation in healthcare.

Limitations:
  • Real patient data cannot be shared without permission from data custodians, which limits external validation of the findings.
  • AI adoption was assumed to be limited in conservative scenarios, which may underestimate the potential impact of AI in real-world settings.
Conclusion:

AI-driven decision support tools have the potential to significantly improve economic outcomes in coronary revascularization by optimizing treatment pathways and reducing costs.

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