To investigate whether endogenous Cushing syndrome (CS) is associated with increased cancer incidence, particularly given the unknown relationship.
Key Findings:
The incidence rate of cancer in patients with CS was 7.77 per 1000 person-years (95% CI 5.84-10.14).
The standardized incidence ratio (SIR) for cancer in patients with CS was 2.08 (95% CI 1.54-2.75).
The most common cancer types among patients with CS were liver (27.7%), kidney (16.7%), and lung (13.0%).
Interpretation:
Patients with endogenous Cushing syndrome have a significantly higher incidence of cancer compared to the general population, suggesting a potential link between CS and cancer risk, which underscores the need for vigilant cancer screening in affected patients.
Limitations:
The study is observational and cannot establish causation.
Data is limited to a single national health insurance system, which may not be generalizable to other populations.
Potential biases inherent in observational studies may affect the results.
Conclusion:
Endogenous Cushing syndrome is associated with an increased risk of cancer, highlighting the need for vigilant cancer screening in affected patients.
