HRS-7535 for Type 2 Diabetes Inadequately Controlled With Metformin: A Randomized Clinical Trial - Summary - MDSpire

HRS-7535 for Type 2 Diabetes Inadequately Controlled With Metformin: A Randomized Clinical Trial

  • By

  • Lixin Guo

  • Zilin Sun

  • Lihui Zhang

  • Guijun Qin

  • Yulan Li

  • Xiaopan Chen

  • Na Xu

  • Xiuhai Su

  • Li Mao

  • Jiao Sun

  • Zhifeng Cheng

  • Xiaoguang Shi

  • Fang Wang

  • Qi Wang

  • Ruirong Pan

  • Shan Ding

  • Zi Ye

  • Yimei Xu

  • Pan Liu

  • June 3, 2026

  • 0 min

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Objective:

To evaluate the efficacy and safety of once-daily oral HRS-7535 as add-on therapy to metformin in adults with type 2 diabetes inadequately controlled by metformin.

Key Findings:
  • HRS-7535 showed a reduction in HbA1c levels compared to placebo, as reported in the study.
  • The safety profile was consistent with other GLP-1 RAs, with no unexpected adverse events reported.
  • Participants receiving HRS-7535 showed improvements in fasting plasma glucose and body weight, as indicated by the study.
Interpretation:

Limitations:
  • The study was limited to a specific population in China, which may affect generalizability.
  • Short duration of the trial may not capture long-term efficacy and safety.
Conclusion:

Original Source(s)

HRS-7535 for Type 2 Diabetes Inadequately Controlled With Metformin: A Randomized Clinical Trial

  • by Lixin Guo, Zilin Sun, Lihui Zhang, Guijun Qin, Yulan Li, Xiaopan Chen, Na Xu, Xiuhai Su, Li Mao, Jiao Sun, Zhifeng Cheng, Xiaoguang Shi, Fang Wang, Qi Wang, Ruirong Pan, Shan Ding, Zi Ye, Yimei Xu, Pan Liu

  • June 3, 2026

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