A Decade-Long Real-World Cohort (2016-2025): Development of an Individualized Risk-Stratification Nomogram and Evaluation of Clinical Utility for Recurrent Respiratory Tract Infections in Children - Summary - MDSpire

A Decade-Long Real-World Cohort (2016-2025): Development of an Individualized Risk-Stratification Nomogram and Evaluation of Clinical Utility for Recurrent Respiratory Tract Infections in Children

  • By

  • Cai, Hehua

  • Li, Juan

  • Wang, Hui

  • April 14, 2026

  • 0 min

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Objective:

To create a personalized risk-stratification nomogram for predicting recurrent respiratory tract infections (RRTIs) in pediatric patients and assess its clinical value.

Key Findings:
  • History of allergy (OR 5.187) and asthma (OR 2.522) were significant predictors of RRTI.
  • Lower vitamin A (OR 0.458) and D levels (OR 0.556), lower birth weight (OR 0.283), passive smoking exposure (OR 2.061), and lower hemoglobin levels (OR 0.425) were also identified as independent predictors.
  • The nomogram showed good discrimination and calibration in both training and testing sets.
Interpretation:

The nomogram effectively stratifies children into low-, intermediate-, and high-risk groups for RRTIs, facilitating targeted prevention strategies.

Limitations:
  • The study may be limited by its observational design and potential confounding factors.
  • Generalizability may be affected by the specific population studied.
Conclusion:

A validated nomogram based on clinical history and nutritional indicators can predict RRTI risk in children, supporting early risk stratification and preventive decision-making.

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