A Decade-Long Real-World Cohort (2016-2025): Development of an Individualized Risk-Stratification Nomogram and Evaluation of Clinical Utility for Recurrent Respiratory Tract Infections in Children - Summary - MDSpire
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A Decade-Long Real-World Cohort (2016-2025): Development of an Individualized Risk-Stratification Nomogram and Evaluation of Clinical Utility for Recurrent Respiratory Tract Infections in Children
To create a personalized risk-stratification nomogram for predicting recurrent respiratory tract infections (RRTIs) in pediatric patients and assess its clinical value.
Key Findings:
History of allergy (OR 5.187) and asthma (OR 2.522) were significant predictors of RRTI.
Lower vitamin A (OR 0.458) and D levels (OR 0.556), lower birth weight (OR 0.283), passive smoking exposure (OR 2.061), and lower hemoglobin levels (OR 0.425) were also identified as independent predictors.
The nomogram showed good discrimination and calibration in both training and testing sets.
Interpretation:
The nomogram effectively stratifies children into low-, intermediate-, and high-risk groups for RRTIs, facilitating targeted prevention strategies.
Limitations:
The study may be limited by its observational design and potential confounding factors.
Generalizability may be affected by the specific population studied.
Conclusion:
A validated nomogram based on clinical history and nutritional indicators can predict RRTI risk in children, supporting early risk stratification and preventive decision-making.