Impact of Various Exercise Modalities on Depression and Anxiety Among Cancer Survivors: A Systematic Review and Bayesian Network Meta-Analysis of Randomized Controlled Trials - Summary - MDSpire
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Impact of Various Exercise Modalities on Depression and Anxiety Among Cancer Survivors: A Systematic Review and Bayesian Network Meta-Analysis of Randomized Controlled Trials
To compare and rank exercise modalities for alleviating depression and anxiety in cancer survivors, estimate optimal doses, and provide specific prescribing guidance.
Key Findings:
Exercise produced small-to-moderate improvements in depression and anxiety compared to non-exercise controls.
Pilates (n=3), Tai Chi (n=11), Qi gong (n=11), and aerobic exercise (n=24) ranked highly for depression relief.
Pilates (n=1) and HIIT (n=2) showed promising effects for anxiety but were based on limited studies.
Optimal exercise prescription for depression is approximately 2.8 METs, 40 minutes per session, six sessions per week.
For anxiety, moderate-intensity exercise five times weekly is recommended.
Interpretation:
Mind-body exercises, particularly Tai Chi and Qi gong, are recommended due to a larger evidence base, while aerobic exercise also shows consistent benefits. Caution is advised for Pilates and HIIT findings due to low certainty of evidence.
Limitations:
Overall certainty of evidence was low due to risk of bias, small-study effects, and imprecision.
Higher BMI and older age may attenuate exercise effects; female proportion showed no significant association.
Conclusion:
Exercise interventions can effectively alleviate depression and anxiety in cancer survivors, with specific recommendations for exercise types and dosages, though individualization is crucial.
