New Tools for Imaging Retinal Inflammation

At ARVO 2026, Ethan A. Rossi, PhD, presented data on multimodal AOSLO imaging of immune cells in the living eye.

By
Jim Gallagher, senior managing editor
May 1, 2026
4 min

Ophthalmology Management

Objective:

To explore the use of multimodal adaptive optics scanning laser ophthalmoscopy (AOSLO) for imaging immune cells in the living eye, particularly in patients with retinal inflammation.

Key Findings:

Identified a range of cellular and structural features associated with inflammation, including immune cell activity and vascular abnormalities.
Dynamic imaging revealed changes in cell morphology and movement over short time intervals, particularly in infectious uveitis cases.
Longitudinal imaging showed that inflammatory features could change with treatment, indicating potential for monitoring disease progression.

Interpretation:

The ability to directly observe immune cell activity and structural changes in the retina may enhance understanding of disease mechanisms and treatment responses, although interpretation of findings remains complex.

Limitations:

Definitive classification of observed cellular structures remains uncertain.
Further data and improved algorithms are needed to enhance the accuracy of image analysis.

Conclusion:

Multimodal AOSLO imaging represents a significant advancement in the visualization of retinal inflammation, offering new insights into the dynamics of immune responses in various retinal diseases.

New Tools for Imaging Retinal Inflammation

Objective:

Key Findings:

Interpretation:

Limitations:

Conclusion:

Original Source(s)

New Tools for Imaging Retinal Inflammation

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