Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial - Summary - MDSpire

Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial

  • By

  • Karen H. Lu

  • Barbara M. Norquist

  • Gary B. Chisholm

  • Christine B. Peterson

  • Kara C. Long Roche

  • Jamie N. Bakkum-Gamez

  • Iris L. Romero

  • Colleen Feltmate

  • Douglas A. Levine

  • Sarah Kim

  • Andrea R. Hagemann

  • Jeanne Carter

  • Martha Hickey

  • Jamie Crase

  • Kathleen Gavin

  • Deborah Polinsky

  • Alan D. D’Andrea

  • Denise R. Nebgen

  • Elizabeth M. Swisher

  • July 7, 2026

  • 0 min

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Objective:

To compare sexual function, menopausal symptoms, and other outcomes in high-risk individuals undergoing ISDO or RRSO for ovarian cancer prevention.

Approach:
  • Study Design: A prospective, multicenter, nonrandomized clinical trial (Women Choosing Surgical Prevention) conducted at 9 US cancer centers.
  • Participants: Premenopausal or perimenopausal individuals aged 30 to 50 years with documented P/LP variants in specific genes.
  • Interventions: Participants self-selected either ISDO or RRSO, with standardized counseling provided.
  • Outcome Measures: Sexual function and menopausal symptoms were assessed using validated questionnaires at baseline, 6, 12, and 24 months post-surgery.
Key Findings:
  • ISDO may delay surgical menopause compared to RRSO.
  • Participants reported changes in sexual function and menopausal symptoms post-surgery.
  • The study highlighted the importance of patient preference in surgical decision-making.
Interpretation:

The findings suggest that ISDO could be a viable alternative to RRSO for high-risk individuals, potentially mitigating some adverse effects associated with surgical menopause.

Limitations:
  • Nonrandomized design may introduce selection bias.
  • Limited generalizability due to specific eligibility criteria.
Conclusion:

The study provides insights into patient preferences and outcomes related to surgical prevention strategies for ovarian cancer.

Original Source(s)

Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial

  • by Karen H. Lu, Barbara M. Norquist, Gary B. Chisholm, Christine B. Peterson, Kara C. Long Roche, Jamie N. Bakkum-Gamez, Iris L. Romero, Colleen Feltmate, Douglas A. Levine, Sarah Kim, Andrea R. Hagemann, Jeanne Carter, Martha Hickey, Jamie Crase, Kathleen Gavin, Deborah Polinsky, Alan D. D’Andrea, Denise R. Nebgen, Elizabeth M. Swisher

  • July 7, 2026

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