Rates of Hospitalization and Death due to COVID-19 in US Veterans With SARS-CoV-2 Infection in the XBB-, JN.1-, and KP-Predominant Eras - Summary - MDSpire
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Rates of Hospitalization and Death due to COVID-19 in US Veterans With SARS-CoV-2 Infection in the XBB-, JN.1-, and KP-Predominant Eras
To investigate the risks of hospitalization and death among US Veterans infected with SARS-CoV-2 during the predominance of the XBB, JN.1, and KP variants from September 2023 to October 2024.
Key Findings:
Hospitalization odds decreased for JN.1 (0.81; 95% CI, 0.74–0.89) and KP (0.80; 95% CI, 0.72–0.88) compared to XBB among 130,263 participants.
In-hospital death rates remained consistently low across all variant eras.
Interpretation:
The study indicates a decline in hospitalization risks among US Veterans infected with newer SARS-CoV-2 variants, with notably low mortality rates across all variants.
Limitations:
The study is limited to the Department of Veterans Affairs patient population, which may not represent the general population.
Potential biases in health care utilization and demographic factors may affect the findings, and missing data could impact results.
Conclusion:
The findings suggest improved outcomes for COVID-19 among US Veterans during the periods dominated by the JN.1 and KP variants.
Protection against spread appeared strongest within 6 months of vaccination, while exposed vaccinated contacts showed no measurable reduction in infection risk.
