Targeted therapy combined with local consolidative surgery for oligometastatic stage IVA lung adenocarcinoma with CCDC6-RET fusion: a case report - Summary - MDSpire
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Targeted therapy combined with local consolidative surgery for oligometastatic stage IVA lung adenocarcinoma with CCDC6-RET fusion: a case report
To report a case of successful surgical resection following initial systemic treatment with selpercatinib in a patient with oligometastatic lung adenocarcinoma harboring a rare CCDC6-RET fusion.
Key Findings:
The patient achieved a partial response to selpercatinib, leading to successful surgical resection.
Postoperative pathology showed 15% residual viable tumor cells, indicating significant tumor shrinkage and raising questions about treatment efficacy.
No recurrence was observed during 7 months of follow-up after surgery.
Interpretation:
This case suggests that for selected patients with oligometastatic lung adenocarcinoma and CCDC6-RET fusion, a multimodal approach combining targeted therapy and surgery may be beneficial, emphasizing the need for careful patient selection and multidisciplinary discussion.
Limitations:
This is a single case report, limiting generalizability.
Further studies are needed to establish broader treatment protocols for similar cases, and long-term follow-up data is lacking.
Conclusion:
The combination of selpercatinib and local consolidative surgery may be a feasible strategy for certain patients with oligometastatic lung adenocarcinoma, though it requires careful patient selection and multidisciplinary discussion.
