Objective:

To evaluate the effectiveness of photodynamic therapy (PDT) combined with CO2 laser treatment compared to CO2 laser monotherapy in reducing condyloma acuminatum (CA) symptoms and enhancing quality of life in patients with early-stage cervical cancer post-radical surgery.

Approach:

Key Findings:

• The PDT cohort showed a higher overall symptom alleviation rate (94.03% vs. 77.78%, P = 0.006).
• Recurrence rates at 3 months were lower in the PDT cohort (7.46% vs. 24.69%) and at 6 months (11.94% vs. 34.57%).
• Quality of life improvements were noted in DLQI (10.46 vs. 11.73, P = 0.001) and FSFI metrics (25.09 vs. 23.83, P = 0.013).
• Significant reduction in viral load was observed in the PDT cohort (0.97 vs. 2.44 ×10^6 copies/mL, P<0.001).
• Adverse events included increased erythema/edema but reduced scarring in the PDT cohort.

Interpretation:

The combination of PDT with CO2 laser treatment improves clinical outcomes and quality of life for patients with CA following cervical cancer surgery.

Limitations:

• Retrospective design may introduce bias.
• Lack of long-term follow-up data.

Conclusion:

The incorporation of photodynamic therapy improves clinical results and quality of life for patients with condyloma acuminatum post-cervical cancer surgery.

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