Early identification of risk factors for obstructive sleep apnea hypopnea syndrome based on large language models - Summary - MDSpire

Early identification of risk factors for obstructive sleep apnea hypopnea syndrome based on large language models

  • By

  • Lei Cheng

  • Juan Bai

  • Aizhu Liu

  • June 15, 2026

  • 0 min

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Objective:

To develop and evaluate a large language model-based framework for early identification of OSAHS-related risk factors and early signals from free-text descriptions, enhancing timely screening and intervention.

Key Findings:
  • OSAHSrisk-LLM achieved an overall accuracy of 92.9% in the four-class text-level classification task, significantly outperforming baseline models including CNN, Text-CNN, Transformer, and BERT.
  • Demonstrated strong robustness under highly imbalanced class distributions and improved identification of minority categories, with a focus on precision and recall metrics.
Interpretation:

Large language models, when integrated with clinical knowledge constraints and structured reasoning strategies, can effectively extract early OSAHS-related risk information from patient narratives. This integration enhances the reliability of the extracted information.

Limitations:
  • Further validation against clinically confirmed OSAHS diagnoses is required to ensure the framework's accuracy in real-world settings.
  • Prospective screening cohorts need to be assessed before real-world clinical application to evaluate the framework's effectiveness.
Conclusion:

The proposed framework demonstrates the potential of large language models to identify textual mentions of OSAHS-related risk factors and early signals in patient-generated narratives.

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