Topical Recombinant Collagen Following Fractional Radio Frequency Microneedling for Nonsurgical Facelift: Case Report - Summary - MDSpire

Topical Recombinant Collagen Following Fractional Radio Frequency Microneedling for Nonsurgical Facelift: Case Report

  • By

  • Thien-Chong Marcus Wong

  • Yizhi Ong

  • June 29, 2026

  • 0 min

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Objective:

To describe the use of topical recombinant collagen in postprocedural care following fractional radiofrequency microneedling (FRM) for nonsurgical facelift, in the context of the absence of established postprocedural care protocols.

Approach:
  • Case Presentation: Two 40-year-old female patients with Fitzpatrick skin type IV and facial laxity underwent FRM and received topical recombinant collagen immediately post-treatment. Clinical assessments were conducted before, immediately after, and 1-2 hours post-treatment, with standardized clinical photography performed under consistent lighting.
Key Findings:
  • Topical recombinant collagen application was associated with a significant reduction in facial edema and erythema within 1-2 hours post-treatment.
  • Patients reported immediate relief from skin discomfort and burning sensation after collagen application.
  • No adverse events or side effects were reported.
Interpretation:

Limitations:
  • Only two patients were included with short-term follow-up.
  • No control group for comparison.
  • Lack of standardized scoring systems for erythema, swelling, or patient-reported outcomes.
Conclusion:

Further evaluation in prospective clinical trials is warranted to assess the role of topical recombinant collagen in postprocedural care following FRM.

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