Case Study: FAPI PET/CT Identifies Hidden Contralateral DCIS and Supraclavicular Metastasis, Informing Neoadjuvant Treatment in Synchronous Bilateral Breast Cancer - Summary - MDSpire

Case Study: FAPI PET/CT Identifies Hidden Contralateral DCIS and Supraclavicular Metastasis, Informing Neoadjuvant Treatment in Synchronous Bilateral Breast Cancer

  • By

  • Lin Cong

  • Bin Ji

  • Yiqi Gu

  • Yilin Wu

  • Wan Wang

  • April 24, 2026

  • 0 min

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Objective:

To demonstrate the efficacy of FAPI PET/CT in identifying hidden contralateral DCIS and supraclavicular metastasis in a patient with synchronous bilateral breast cancer, highlighting its clinical significance.

Key Findings:
  • FAPI PET/CT detected occult contralateral DCIS and supraclavicular metastasis that FDG PET/CT missed, emphasizing its clinical utility.
  • FAPI PET/CT demonstrated superior sensitivity in identifying low-metabolic malignancies.
  • Post-treatment imaging indicated a complete response in lymph nodes.
Interpretation:

FAPI PET/CT is a valuable diagnostic tool that enhances the detection of low-metabolic tumors and improves staging accuracy in breast cancer.

Limitations:
  • The study is based on a single case, limiting generalizability and introducing potential biases.
  • Further studies are needed to validate FAPI PET/CT's efficacy across diverse breast cancer subtypes.
Conclusion:

FAPI PET/CT significantly improved the diagnostic and therapeutic approach for the patient, highlighting its potential role in breast cancer management.

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