Hepatitis C Virus Testing in Perinatally Exposed Children - Summary - MDSpire

Hepatitis C Virus Testing in Perinatally Exposed Children

  • By

  • Rachel L. Epstein

  • Sarah Munroe

  • Elizabeth A. Erdman

  • Amy Bettano

  • Megan R. Curtis

  • Laura White

  • Elisha M. Wachman

  • Anthony Osinski

  • Alexander Y. Walley

  • Benjamin P. Linas

  • April 17, 2026

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Objective:

To characterize trends in perinatal HCV exposure, testing, and treatment in Massachusetts and identify factors associated with improved testing practices.

Approach:
    Key Findings:
    • HCV prevalence among pregnant persons increased to 4.9 cases per 1000 live deliveries by 2019, indicating a significant public health concern.
    • Only 30.1% of exposed infants were appropriately tested for HCV under previous guidelines, highlighting a critical gap in care.
    • CDC now recommends RNA testing for infants exposed to HCV at ages 2 to 6 months to improve follow-up rates and ensure timely intervention.
    Interpretation:

    The study highlights significant gaps in HCV testing for perinatally exposed infants, emphasizing the urgent need for targeted interventions to improve testing rates and treatment access.

    Limitations:
    • Study findings may not be generalizable beyond Massachusetts, limiting broader applicability.
    • Data limitations due to potential underreporting and lack of sociodemographic adjustments in previous studies may affect the robustness of conclusions.
    Conclusion:

    Improving HCV testing practices for perinatally exposed infants is crucial for achieving national HCV elimination goals by 2030, underscoring the need for effective public health strategies.

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