Incidence of Human Metapneumovirus Among Older Adults in 10 High-Income Countries: A Systematic Literature Review, Meta-analysis, and Modeling Study - Summary - MDSpire
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Incidence of Human Metapneumovirus Among Older Adults in 10 High-Income Countries: A Systematic Literature Review, Meta-analysis, and Modeling Study
To quantify the incidence of lower respiratory infections (LRI) associated with human metapneumovirus (hMPV) in older adults across ten high-income countries (Canada, Chile, France, Germany, Italy, New Zealand, Spain, Netherlands, United Kingdom, and United States) in 2019.
Key Findings:
hMPV accounts for 7.0% of LRI cases in older adults (95% CI, 5.4%–9.1%).
Estimated hMPV incidence rates per 100,000 in 2019 ranged from 185.7 (95% UI, 134.7–251.1) in Italy to 462.1 (95% UI, 333.1–628.2) in the United States.
Significant burden of hMPV-associated LRI in older adults was confirmed.
Interpretation:
The study highlights a critical evidence gap in the epidemiology of hMPV, indicating a substantial burden of disease among older adults that warrants further surveillance and research to inform public health policy.
Limitations:
Focused only on ten high-income countries, limiting generalizability.
Potential underdiagnosis of hMPV in older adults due to atypical presentation.
Possible biases in the studies included in the review.
Conclusion:
The findings underscore the need for routine surveillance of hMPV to better understand its incidence and inform vaccine development strategies.
