To explore the associations between PFAS exposures and thyroid homeostasis parameters in adults, specifically focusing on both central and peripheral sensitivity indicators.
Key Findings:
Positive associations were found between PFAS exposure and peripheral thyroid hormone sensitivity indicators (FT3/FT4 and SPINA-GD), with PFOA identified as having the highest weight in the models.
No significant associations were observed between PFAS exposure and central thyroid sensitivity parameters.
Interpretation:
PFAS exposures may primarily affect peripheral thyroid hormone sensitivity rather than central regulation among US adults, indicating potential health implications that warrant further investigation.
Limitations:
Cross-sectional design limits causal inference.
Potential confounding factors, such as dietary influences and other environmental exposures, were not fully accounted for.
Conclusion:
The study enhances understanding of the relationship between PFAS exposure and thyroid hormone dynamics, suggesting a critical need for further research on health implications.
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