To conduct a bibliometric analysis of pediatric nephrotic syndrome (NS) and indicate its current status, hot spots, and directions of future studies.
Approach:
Data Collection: Literature data were collected from the Web of Science Core Collection and Scopus.
Analysis Tools: CiteSpace, VOSviewer, and Biblioshiny (Bibliometrix package) were employed for visualized bibliometric analysis.
Publication Review: A total of 2,873 publications from 2011 to 2025 were analyzed.
Key Findings:
China contributed the most articles (452), but its centrality remained low (0.01).
Assistance Publique Hopitaux Paris in France had the highest number of publications (77).
Iijima Kazumoto ranked first among authors with 58 publications.
Prominent keywords included 'nephrotic syndrome', 'children', and 'focal segmental glomerulosclerosis'.
Emerging topics included 'nphs2', 'bone mineral density', 'glomerulonephritis', and 'periorbital edema'.
The latest burst keywords included 'leukocyte count', 'lipoid nephrosis', 'unclassified drug', 'estimated glomerular filtration rate', and 'alport syndrome'.
Interpretation:
The study clarified the current research status and identified future research hotspots and development trends in pediatric nephrotic syndrome.
Limitations:
The study did not include non-English publications.
The analysis was limited to articles and reviews, excluding other types of publications.
Conclusion:
The exploration of novel immunosuppressants and elucidation of complex pathogenic mechanisms are ongoing research hotspots in pediatric nephrotic syndrome.
