Progress and prospects for herpesvirus vaccination using gB antigens - Summary - MDSpire

Progress and prospects for herpesvirus vaccination using gB antigens

  • By

  • Solomon English

  • Adam Khan-Qureshi

  • Alexander D. Douglas

  • May 29, 2026

  • 0 min

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Objective:

To review current knowledge regarding gB as a vaccine antigen for herpesviruses and assess its potential in vaccine development.

Key Findings:
  • gB is a conserved glycoprotein across herpesviruses and plays a crucial role in membrane fusion during cell invasion.
  • Current vaccines targeting gB have shown partial efficacy, particularly in HCMV clinical trials.
  • Recent advancements in stabilizing the pre-fusion conformation of gB may enhance immunological protection.
Interpretation:

The review critically appraises the potential of gB antigens in future herpesvirus vaccines, considering their structural and functional properties.

Limitations:
  • gB-targeting vaccines have received less attention compared to vaccines against receptor-binding glycoproteins.
  • There is uncertainty regarding the optimal immune responses that gB-based vaccines should induce.
Conclusion:

The potential for gB antigens to contribute to future herpesvirus vaccines remains significant, but further research is needed to address key uncertainties.

Original Source(s)

Progress and prospects for herpesvirus vaccination using gB antigens

  • by Solomon English, Adam Khan-Qureshi, Alexander D. Douglas

  • May 29, 2026

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