Age-related changes in lens thickness in children aged 3-17 years and its association with myopia and ocular biological parameters: a cross-sectional and longitudinal study - Summary - MDSpire
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Age-related changes in lens thickness in children aged 3-17 years and its association with myopia and ocular biological parameters: a cross-sectional and longitudinal study
To investigate age-related changes in lens thickness (LT) and its associations with ocular biometrics and refractive status in children aged 3–17 years.
Key Findings:
Median LT was 3.42 mm, significantly negatively correlated with age (r=-0.434, P<0.001).
LT showed a triphasic pattern: significant decrease before age 10, stabilization at 10–12 years, and mild thickening after age 13.
Females had thicker LT than males (3.46±0.22 vs. 3.41±0.20 mm; P<0.001).
LT negatively correlated with AL (r=-0.512) and ACD (r=-0.595), but not with Km or CCT.
Non-myopic children had thicker LT than myopic children (3.54±0.22 vs. 3.35±0.15 mm; P<0.001).
Interpretation:
LT follows an age-dependent pattern with early decline, stabilization during adolescence, and subsequent thickening, indicating potential compensatory mechanisms in refractive development.
Limitations:
Retrospective design may limit causal inferences.
Sample size for longitudinal data may affect the robustness of findings.
Conclusion:
Age 10 represents a critical intervention window, with LT serving as a potential biomarker for pediatric refractive status assessment.
