Objective:

To assess the thickness of retinal layers, pRNFL, MRW parameters, and subfoveal choroidal thickness in eyes with clinically unilateral PEXS, their unaffected fellow eyes, and healthy controls, highlighting the significance of these assessments in understanding disease progression.

Key Findings:

• Significant differences in retinal layer thicknesses between affected eyes, fellow eyes, and healthy controls were observed, with specific measurements provided.
• Changes in macular and peripapillary regions were noted in eyes with unilateral PEXS, indicating structural alterations.
• Subfoveal choroidal thickness showed variations correlating with PEXS presence, suggesting a potential biomarker.

Interpretation:

The study indicates that unilateral PEXS is associated with measurable structural changes in retinal layers, suggesting potential early markers for disease progression and implications for clinical monitoring.

Limitations:

• The study's sample size may limit the generalizability of the findings, and the short follow-up duration does not allow for assessment of long-term changes, which could affect the robustness of conclusions.

Conclusion:

Identifying retinal structural changes in unilateral PEXS may enhance understanding of the disease's impact and aid in early detection of glaucoma, emphasizing the need for ongoing monitoring and research.