Objective:

To investigate the real-world experiences of patients with chronic spontaneous urticaria (CSU) in China, focusing on disease control patterns, healthcare utilization, treatment satisfaction, quality of life impact, and financial burden.

Approach:

• Study Design: An internet-based cross-sectional observational study using a structured online survey.
• Population: Patients with CSU in China were recruited through healthcare professionals, patient communities, and third-party vendor panels.
• Data Collection: Conducted between August 2025 and October 2025, capturing patient characteristics and treatment stages.

Key Findings:

• 35% of actively treated patients report inadequate disease control (UCT < 12).
• 90% of inadequately controlled patients experience sleep disturbances during exacerbations.
• 39% report feeling moody, and 28% rate their professional life impact as moderate to severe (≥ 5 on a 10-point scale).
• 84% of patients rate complete symptom control as highly important, but only 16% believe it achievable.
• 38% of patients used Traditional Chinese Medicine alongside conventional treatments.
• Only 7% of patients recommended for advanced therapies actually utilized them.

Interpretation:

The study reveals significant gaps in disease control and treatment satisfaction among CSU patients in China, highlighting a misalignment between patient needs and healthcare infrastructure.

Limitations:

• No direct medical record verification was feasible.
• Potential biases in self-reported data.
• The study's reliance on an online survey may limit the generalizability of the findings.

Conclusion:

This study provides the first large-scale assessment of CSU management gaps in China, emphasizing the need for improved treatment access and patient care.