Glioblastoma survival in rural America: a 10-year experience from a quaternary care center - Summary - MDSpire

Glioblastoma survival in rural America: a 10-year experience from a quaternary care center

  • By

  • Pack, Emily

  • Cifarelli, Christopher P.

  • Bhatia, Sanjay

  • Lewis, Jeremy

  • Brandmeir, Nicholas

  • Gleckman, Aaron

  • Han, Peng Cheng

  • Wages, Nolan A.

  • Dotson, Timothy Shaun

  • Denney, Morgan W.

  • Wen, Sijin

  • Armistead, Matthew

  • Norouzi, Saeed

  • Aulakh, Sonikpreet

  • March 10, 2026

  • 0 min

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Objective:

To evaluate survival differences in glioblastoma (GBM) patients based on treatment and demographic factors, particularly focusing on rural versus urban residency, age, and sex.

Key Findings:
  • The cohort consisted of 380 patients, predominantly male (58.2%) and older than 65 years (48.2%).
  • Standard-of-care therapies were received by 66.8% (TMZ), 88.4% (surgical resection), and 59.5% (radiation therapy) of patients.
  • Rural patients faced significant barriers to treatment adherence, impacting survival outcomes, with a notable difference in treatment completion rates.
Interpretation:

Centralized neuro-oncology care may significantly improve GBM outcomes, highlighting the critical need for access to specialized treatment in rural areas.

Limitations:
  • The study is retrospective and may be subject to selection bias.
  • Findings are based on a single institution, which may limit generalizability.
  • Potential confounding factors may not have been fully accounted for in the analysis.
Conclusion:

Improving access to centralized care for GBM patients in rural areas could enhance survival outcomes and address healthcare disparities.

Original Source(s)

Glioblastoma survival in rural America: a 10-year experience from a quaternary care center

  • by Pack, Emily, Cifarelli, Christopher P., Bhatia, Sanjay, Lewis, Jeremy, Brandmeir, Nicholas, Gleckman, Aaron, Han, Peng Cheng, Wages, Nolan A., Dotson, Timothy Shaun, Denney, Morgan W., Wen, Sijin, Armistead, Matthew, Norouzi, Saeed, Aulakh, Sonikpreet

  • March 10, 2026

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