Objective:

To investigate long-term clinical and lived impacts of subtotal pancreatectomy for diffuse congenital hyperinsulinism (HI) as reported by affected families.

Approach:

Key Findings:

• 71% of participants underwent subtotal pancreatectomy before two months of age (24 out of 34).
• Only 9% (3 out of 34) had normal glucose status at discharge.
• At follow-up, 44% (15 out of 34) reported diabetes, 41% (14 out of 34) pancreatic insufficiency, and 24% (8 out of 34) ongoing medication for hypoglycemia.
• Continuous glucose monitoring showed suboptimal time in range regardless of diabetes status.
• Caregivers reported high stress and mental health challenges during hospitalization and post-discharge.

Interpretation:

Subtotal pancreatectomy may be necessary for managing severe hypoglycemia in diffuse HI, but it is not curative and leads to lifelong management challenges.

Limitations:

• Small sample size for qualitative interviews.
• Potential selection bias in participant recruitment.

Conclusion:

The study reports the long-term impacts of subtotal pancreatectomy on patients with diffuse HI and their families.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.