Comparative diagnostic performance of C-TIRADS versus Kwak TI-RADS for thyroid nodules: implications for fine-needle aspiration biopsy referral - Summary - MDSpire

Comparative diagnostic performance of C-TIRADS versus Kwak TI-RADS for thyroid nodules: implications for fine-needle aspiration biopsy referral

  • By

  • Li Xia

  • Anjie Chen

  • Li Kang

  • Shiming Guan

  • Qing Luy

  • June 4, 2026

  • 0 min

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Objective:

To assess the developmental trends of thyroid nodules over an extended follow-up period and evaluate the diagnostic efficacy of C-TIRADS compared to Kwak TI-RADS, highlighting the importance of these assessments in clinical practice.

Key Findings:
  • The AUC for C-TIRADS was 0.784, with a category of ≥4B yielding sensitivity of 75.72% and specificity of 75.76%.
  • No statistically significant difference was found in diagnostic efficacy between C-TIRADS and Kwak TI-RADS.
  • Microcalcifications, irregular margins, and internal vascularity were increasingly observed in nodules over time.
Interpretation:

C-TIRADS demonstrates diagnostic accuracy comparable to Kwak TI-RADS, reinforcing its clinical utility in thyroid nodule management.

Limitations:
  • Study conducted at a single center, which may limit generalizability and applicability to broader populations.
  • Exclusion of indeterminate cases may affect the overall findings and limit the understanding of diagnostic performance.
Conclusion:

C-TIRADS is clinically useful for thyroid nodule management, showing similar diagnostic performance to Kwak TI-RADS.

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