Time-restricted eating versus calorie restriction for improving biomarkers of age in adults with overweight or obesity and incipient fatty liver disease: protocol for the ENSATI randomized controlled parallel groups trial. - Summary - MDSpire

Time-restricted eating versus calorie restriction for improving biomarkers of age in adults with overweight or obesity and incipient fatty liver disease: protocol for the ENSATI randomized controlled parallel groups trial.

  • By

  • Celada, José A.

  • Rubio-Gordón, Laura

  • Jiménez-Perez, Yolanda

  • López-Lora, Lorena

  • López-González, Andrés

  • Delbuono, Sara

  • Huertas, Ana

  • Martínez-Urbistondo, Diego

  • Ordovas, Jose M

  • de la O, Víctor

  • Daimiel, Lidia

  • May 28, 2026

  • 0 min

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Objective:

To compare the effects of time-restricted eating and caloric restriction on age-related biomarkers in overweight or obese adults with early fatty liver disease.

Key Findings:
  • The ENSATI trial addresses limitations of previous studies by having a longer duration, larger sample size, and rigorous dietary monitoring.
Interpretation:

Limitations:
  • The study is limited to a specific age group (50-70 years) and population (overweight/obese adults with early fatty liver disease).
  • Results may not be generalizable to other demographics or those without fatty liver disease.
Conclusion:

Sources:

Original Source(s)

Time-restricted eating versus calorie restriction for improving biomarkers of age in adults with overweight or obesity and incipient fatty liver disease: protocol for the ENSATI randomized controlled parallel groups trial.

  • by Celada, José A., Rubio-Gordón, Laura , Jiménez-Perez, Yolanda , López-Lora, Lorena , López-González, Andrés , Delbuono, Sara , Huertas, Ana , Martínez-Urbistondo, Diego , Ordovas, Jose M, de la O, Víctor , Daimiel, Lidia

  • May 28, 2026

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