The percentage abundance of sarcomatoid component has a prognostic role in grade 4 non-metastatic clear cell-renal carcinoma - Summary - MDSpire

The percentage abundance of sarcomatoid component has a prognostic role in grade 4 non-metastatic clear cell-renal carcinoma

  • By

  • Giuseppe Lucarelli

  • Francesco Lasorsa

  • Monica Rutigliano

  • Martina Milella

  • Marco Spilotros

  • Antonio d’Amati

  • Giuseppe Ingravallo

  • Felice Crocetto

  • Savio Domenico Pandolfo

  • Marco Fabiano

  • Matteo Ferro

  • Riccardo Autorino

  • Michele Battaglia

  • Pasquale Ditonno

  • April 23, 2025

  • 0 min

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Objective:

To evaluate the prognostic impact of the percentage abundance of intratumor sarcomatoid features in patients with non-metastatic clear cell renal cell carcinoma (ccRCC).

Key Findings:
  • 55.2% of patients had high sarcomatoid (HS) component (≥20%), while 44.8% had low sarcomatoid (LS) component (<20%).
  • HS patients had larger tumor masses compared to LS patients (P = 0.001).
  • Cut-off of 20% for sarcomatoid component was significant for cancer-specific survival (CSS) and recurrence-free survival (RFS) with AUCs of 0.61 and 0.60 respectively.
Interpretation:

The percentage of sarcomatoid component in ccRCC is a significant prognostic factor, with higher abundance correlating with worse outcomes.

Limitations:
  • Retrospective design may introduce selection bias.
  • Limited generalizability due to the specific cohort studied.
Conclusion:

The abundance of sarcomatoid features in grade 4 ccRCC is a valuable prognostic indicator, aiding in risk stratification and management decisions.

Original Source(s)

The percentage abundance of sarcomatoid component has a prognostic role in grade 4 non-metastatic clear cell-renal carcinoma

  • by Giuseppe Lucarelli, Francesco Lasorsa, Monica Rutigliano, Martina Milella, Marco Spilotros, Antonio d’Amati, Giuseppe Ingravallo, Felice Crocetto, Savio Domenico Pandolfo, Marco Fabiano, Matteo Ferro, Riccardo Autorino, Michele Battaglia, Pasquale Ditonno

  • April 23, 2025

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