Brain cortex activity of patients with disorders of consciousness under familiar and unfamiliar voice of subject's own name: an fNIRS-based study - Summary - MDSpire
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Brain cortex activity of patients with disorders of consciousness under familiar and unfamiliar voice of subject's own name: an fNIRS-based study
To investigate the real-time cortical activation elicited by auditory sensory stimulation through familiar voice of subject's own name (FV SON) vs. unfamiliar voice of subject's own name (UFV SON) in patients with disorders of consciousness (DOC).
Key Findings:
Participants with DOC under UFV SON stimulation exhibited deactivation in the Left Dorsolateral Pre-frontal Cortex (DLPFC-L).
Under FV SON stimulation, participants did not show deactivation in the DLPFC-L compared to rest state.
The peak value in DLPFC-L was greater under FV SON compared to UFV SON.
Positive correlations were found between peak values in DLPFC-L and TC-L under FV SON stimulation with CRS-R VFS scores.
Under UFV SON stimulation, various cortical areas showed positive correlations with different CRS-R scores.
Interpretation:
Distinct cortical activation patterns were observed in DOC patients under familiar vs. unfamiliar SON calling stimulation.
Limitations:
The study's conclusions warrant further validation in larger, multicenter studies.
The study did not explore the long-term effects of auditory stimulation.
Conclusion:
The findings provide insights for guiding auditory stimulation strategies or personalized rehabilitation in DOC.
