Feasibility of embryonic-natural orifice transluminal endoscopic surgery for submucosal tumors with mucosal preservation in beagle model - Summary - MDSpire
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Feasibility of embryonic-natural orifice transluminal endoscopic surgery for submucosal tumors with mucosal preservation in beagle model
To evaluate the feasibility and safety of embryonic-natural orifice transluminal endoscopic surgery (E-NOTES) for the resection of gastric muscularis propria-originating submucosal tumors (MP-SMTs) while preserving mucosal integrity.
Key Findings:
All procedures were completed successfully without conversion to laparoscopy.
Mean simulated lesion diameter was 28.1 ± 7.7 mm, and mean operative time was 64.3 ± 5.5 min.
Minor intraoperative bleeding occurred in 58.3% of dogs but was controlled endoscopically.
No severe complications such as perforation or major bleeding occurred.
All animals resumed oral intake within 24 hours, and complete mucosal healing was confirmed at 60 days.
Interpretation:
E-NOTES demonstrated a safe and effective method for resecting gastric MP-SMTs while preserving mucosal integrity, with low complication rates and rapid recovery.
Limitations:
The study was conducted in a small sample size of beagles, limiting generalizability.
Long-term outcomes and potential complications in humans remain to be evaluated.
Conclusion:
E-NOTES is a promising technique for the minimally invasive resection of gastric MP-SMTs, warranting further technical refinement and evaluation in future studies.
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